Memorial Wall 2020

7 days ago

2 weeks ago

Eric Vallabh MinikelEric Vallabh MinikelEric Vallabh Minikel• 1st• 1stPrion scientist at Broad InstitutePrion scientist at Broad Institute6d • 6 days agoPublished today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: lnkd.in/d7rUpnq8The lightning summary:- Drug programs supported by human genetics are more successful, almost regardless of the nature of the genetic evidence- Increase in success rate may be especially large for disease-modifying therapies- Genetics still underutilized in picking targetsHere is a thread breaking down the findings panel by panel: lnkd.in/d-4f5FGuIt was my privilege to work with the best on this project, and I want to say a huge thanks to Matthew Nelson for teaching me so much about complex trait genetics that I "should" know as a Broadie but didn't, and to Coco Dong for teaching me to write better code (finally, after all these years, joining the tidyverse) ... See MoreSee Less

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CJD Support Group Network

2 weeks ago

Congratulations to our colleagues and friends who make the Australian National CJD Registry (ANCJDR) one of the top prion disease surveillance units in the world.https://www.facebook.com/photo?fbid=830712455768198&set=a.560287242810722 ... See MoreSee Less

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CJD Support Group Network

4 weeks ago

Blog from Eric Minikel discussing the reasons for the clinical trial pause and what it means. ... See MoreSee Less

Why the ION717 trial is paused

www.cureffi.org

Probably because they filled the lowest dose group and need to analyze the safety and pharmacology data before escalating to a higher dose.

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CJD Support Group Network

4 weeks ago

The Ionis Community Statement explaining the pause for Phase 1 Recruitment in current clinical trials will be available on our website . They explain well the reasons for the pause. There are also FAQ's on page 2. Sites will continue to open including Australia but recruitment of new patients will only begin again when we are advised that the pause is completed. Patients who have already been recruited in sites already open globally will continue on the trial. Please read the statement for more details www.cjdsupport.org.au/trial-update-for-prion-diseases/ ... See MoreSee Less

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