Gate Bioscience is creating a new category of medicines called Molecular Gates. Our therapeutics are small molecules that selectively eliminate harmful extracellular proteins at their origin, inside the cell. We are working to develop a small molecule therapeutic to selectively eliminate prion protein (PrP) in the brain. If successful, this work could lead to an orally available PrP-lowering medicine: in effect, a pill to treat or prevent prion disease. Gate Bioscience’s Prion therapeutic is in preclinical development and is not yet ready for clinical trials.